Evaluation of serum adipokines with the development of metabolic syndrome among industrial workers

Abstract

Ravi Prakash Jamalpur, Vinay Kumar Adepu, Surender Jakkam, Ravibabu Kalahasthi

Background: Most of the studies were reported serum adipokines with the presence of metabolic syndrome (MetS) in population-based studies. Objective: The present study assessed the levels of serum adipokines, i.e., leptin, adiponectin, leptin:adiponectin ratio (LAR), and adiponectin:leptin ratio (ALR), and the development of MetS among industrial workers. Methods: Eighty-eight workers were recruited in the study. MetS was diagnosed using the definition of the International Diabetes Federation. Serum leptin and adiponectin levels were done using enzyme linked immunosorbent assay methods. LAR and ALR values were calculated using the serum leptin and adiponectin. The data was analyzed using statistical package for the social sciences software. Mann–Whitney U test was used to find out the differences of adipokines among workers with or without MetS. Kruskal– Wallis test was used to find out the effect of the number of metabolic components (0, 1, 2, 3, and >4) on serum adipokines among workers. Results: 37.5% of workers had MetS. The levels of serum leptin (p < 0.01) and LAR (p < 0.01) were significantly increased and serum adiponectin (p = 0.104) and ALR (p < 0.01) were decreased in workers with the presence of MetS. The effect of the number of metabolic components was demonstrated a significant increase of serum leptin (p = 0.018) and LAR (p = 0.026) and significant decrease of ALR (p = 0.046). Conclusion: The levels of serum leptin and LAR were increased and adiponectin and ALR were decreased in workers with the presence of MetS and the number of metabolic components. The data of the present study support the role of adipokines and development of MetS. It could be used as specific indicators for the diagnosis and management of MetS